The Goldfish as a Model for Studying Neuroestrogen Synthesis, Localization, and Action in the Brain and Visual System

Organizational and activational effects of estrogen (E) in the central nervous system (CNS) are exerted directly by circulating E and indirectly after aromatization of circulating androgen to E in the brain itself. Understanding an environmental chemical's ability to disrupt E-dependent neural processes, therefore, requires attention to both pathways. Because aromatase (Aro) is highly expressed in teleost brain, when compared to mammals and other vertebrates, fish are technically advantageous for localization and regulation studies and may also provide a model in which the functional consequences of brain-derived (neuro-)E synthesis are exaggerated. Recently, Aro was immunolocalized in cell bodies and fiber projections of second- and third-order neurons of the goldfish retina and in central visual processing areas. Authentic Aro enzyme activity was verified biochemically, suggesting a heretofore unrecognized role of sex steroids in the visual system. Initial studies show that in vivo treatment with aromatizable androgen or E increases calmodulin synthesis and calmodulin protein in retina and also affects retinal protein and DNA. Whether there are related changes in the processing of visual information that is essential for seasonal reproduction or in the generative and regenerative capacity of the goldfish visual system requires further investigation. IMAGES.National Science Foundation (DCB8916809

Planning for the upgrading of informal settlements

Planning for the upgrading of informal settlements is still a relatively unknown field for planners in South Africa and it is certain to receive more attention in future. The role of the upgrading of informal settlements in providing low income housing will be discussed, as well as certain factors that play an important role in planning projects of this kind. A "strategy", involving certain alternative solutions available to the planner in the field, will then be put forward. Findings from a study done in Joe Slovo Square, Bloemfontein, will be used to illustrate the article

The NASA/GSFC hydrogen maser program: A review of recent data

Data is presented on the phase and frequency stability, over time periods extending to one week, of the new NR field operable hydrogen masers developed by the Applied Physics Laboratory (APL) and the older NX and NP field operable hydrogen masers developed by Goddard Space Flight Center and maintained and upgraded by Bendix Field Engineering Corporation (BFEC). Data is presented on the NR masers in the laboratory showing frequency stabilities well into the 10 to the -15th power range and phase stabilities well into the 100 ps range for periods of up to one day. Data is presented on upgraded NP masers in the laboratory showing that the frequency stability has been improved substantially to virtually the NR level. VLBI data is presented on the phase difference between NX-2 at Owens Valley, California and NR-2 at Fort Davis, Texas for a one week period showing, after removal of a constant frequency drift, a 350 ps RMS phase stability

FZZ Scattering

We study the duality between the two dimensional black hole and the sine-Liouville conformal field theories via exact operator quantization of a classical scattering problem. The ideas are first illustrated in Liouville theory, which is dual to itself under the interchange of the Liouville parameter b by 1/b. In both cases, a classical scattering problem does not determine uniquely the quantum reflection coefficient. The latter is only fixed by assuming that the dual scattering problem has the same reflection coefficient. We also discuss the relation of this approach to the method that exploits the parafermionic symmetry of the model to compute the reflection coefficient.Comment: 19 pages, JHEP style. v2: Minor changes in the proposed field of sine-Liouville type, new section discussing the relation with parafermionic symmetry, references adde

Developing and improving quality efficiency in the South Africa energy industry

Businesses today need to be more effective and efficient in order to design the best products and provide outstanding services to their customers. The purpose of this research is to develop and improve quality efficiency while sustaining continuous improvement at a South African Energy provider's Mpumalanga plant, which is one of the nine regions in South Africa. Accomplishing quality efficiency is challenging, as customers expect quality of service at all times. In general an organisation's or a business's success depends on the reliability of delivering electricity. Therefore the South African Energy provider should be able and capable to deliver electricity at all times. Current research results revealed that: (1) organisations need to do more to raise quality awareness and inform other employees about the quality unit, (2) organisations should go the extra mile in planning, monitoring and evaluating quality, (3) departmental quality objectives and goals should involve employees in formulating the goals and objectives, eliminating misunderstanding and mistakes committed by the workforce where quality is concerned, (4) management should be committed and involved in accomplishing quality efficiency in any capacity and making sure that continuous improvement is sustained, (5) commitment by management and employee recognition will improve capability, performance and innovation. The research study accordingly has a realistic and methodological significance in terms of achieving and improving quality efficiency and sustaining continuous improvement in providing energy in South Africa

Perceived Water Quality and Reported Health among Adults during the Flint, MI Water Crisis

Background and Purpose: In April 2014, the municipal water source for Flint, Michigan was changed from Lake Huron to the Flint River. Although residents reported concerns about the quality of tap water and resulting health problems, officials insisted that the water was safe. This study examined relationships between self-reported tap water quality during the water crisis and health conditions among Flint residents. Methods: Participants from each residential Census Tract in the City of Flint were recruited via address lists, online social media, and community-based events. The survey included mental and physical health items from the CDC’s Behavioral Risk Factor Surveillance System and an item on tap water quarter quality experiences. Analyses were weighted to be demographically representative. Results: Participants (N = 277) rated their tap water quality (taste, smell, appearance) as Poor (57%), Fair (20%), Good (13%), Very Good (6%), and Excellent (3%). Controlling for age, gender, years of education, whether respondents were African American or Hispanic/Latino/a, and population demographics, lower perceived tap water quality was associated with worse mental and physical health across all indicators. Conclusion: This study demonstrates associations of tap water quality experiences with reported poor physical and mental health among adults in Flint during the Flint Water Crisis